Brown Adipose Tissue Ca2+-ATPase
نویسندگان
چکیده
منابع مشابه
Brown adipose tissue Ca2+-ATPase: uncoupled ATP hydrolysis and thermogenic activity.
In this report a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) was identified in rats brown adipose tissue. Electrophoretic analysis of brown fat microssomal protein yields a 110-kDa band that is reactive to SERCA 1 antibody but is not reactive to SERCA 2 antibodies. Nevertheless, the kinetics properties of the brown fat SERCA differ from the skeletal muscle SERCA 1 inasmuch they manifest a d...
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1Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Molecular Epidemiology, Graduate School of Medicine, Kobe University, Kobe, Japan; 3First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan; 4Biology Laboratory Research Center, Daiichi Radioisotope Laboratories, Limited, Chiba, Japan; and 5Department of Anatomy, Meiji Colleg...
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The effect of acclimation at different temperatures on the act iv i ty of interscapular brown adipose tissue has been i nves t i ga ted in the hamster, a h ibernator . Between 3l ~ and ~~ the cytochrome oxidase act iv i ty of the tissue increased z~_ to 5-fold, mitochondrial GDP binding per mg of mitochondrial protein doubled, and the amount of uncoupling protein rose from 1.7% to 5.4% of total...
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The recent discovery of functional brown adipose tissue in human adults raised this tissue again into the focus of current investigations concerning human energy homeostasis. Brown fat is a key thermogenic tissue and is essential for non-shivering thermogenesis in the human newborn and hibernating mammals. This review highlights the biological and molecular aspects of brown adipose tissue devel...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m308280200